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Dose | Control | 1% GF | 2% GF |
Rat ID no. | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 82 | 85 | 86 | 88 | 90 |
Tissue observation |
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Ileum (H&E and Masson trichrome staining) | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
Colon | | | | | | | | | | | | | | | | | | | | | | | |
Deposit, eosinophilic, lamina propria | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — | — |
Fibrosis, mesocolon, perivenus region | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — | — |
Fibrosis, lamina propria (Masson trichrome staining) | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — | — |
Mesentery (H&E and Masson trichrome staining) | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
Spleen | | | | | | | | | | | | | | | | | | | | | | | |
Decreased pigmentation (hemosiderin) | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 2 | — | 1 | — |
Increased extramedullary hematopoiesis | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — | — | — | — |
Decreased lymphoid cell PALS | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — |
Liver | | | | | | | | | | | | | | | | | | | | | | | |
Cell infiltration (lymphoid cell), periportal | — | — | 1 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 2 | 1 | 1 | 1 | 1 |
Pigmentation (brown, granular), hepatocyte | — | — | — | — | — | — | — | — | — | — | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Atrophy, hepatocyte, centrilobular | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | 1 | 2 | 1 | 1 |
Decreased vacuole, periportal hepatocyte | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | 2 | — | — |
Vacuolation, hepatocellurar, focal | — | — | — | 1 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
Vacuolation, hepatocellurar, periportal | — | — | — | — | 1 | — | — | — | 1 | — | 1 | — | — | 1 | 1 | — | — | — | 1 | 1 | — | — | — |
Regeneration, hepatocellular, focal | — | — | — | — | — | — | — | — | — | — | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Adrenal | | | | | | | | | | | | | | | | | | | | | | | |
Congestion/hemorrhage, cortex | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — |
Kidney | | | | | | | | | | | | | | | | | | | | | | | |
Mineralization, corticomedullary junction | 2 | 1 | — | — | 1 | — | — | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 2 | 1 | 2 | 2 |
Pigmentation (brown, granular), proximal tubule | — | — | — | — | — | — | — | — | — | — | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 2 |
Cast, focal | — | P | — | — | — | — | — | — | — | — | P | — | — | P | P | — | — | P | — | P | 2 | — | — |
Fibrosis, cortex, focal | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — | — | — |
Chronic progressive nephritis | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — | — |
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