Review Article

Nonhormonal Hot Flash Management for Breast Cancer Survivors: A Systematic Review and Network Meta-Analysis

Table 2

Results of network meta-analysis.

Hot flash frequency

Lifestyle changes
0.53 (−3.44, 4.51)Mind-body techniques
5.69 (−66.24, 79.85)5.17 (−66.73, 79.47)Dietary/supplements
2.59 (−70.16, 76.88)2.06 (−70.72, 76.47)−3.1 (−13.54, 7.32)SSRIs/SNRIs
7.79 (−64.32, 82.02)7.27 (−64.95, 81.44)2.1 (−3.92, 8.13)5.21 (−6.22, 16.66)Other medications
7.82 (−64.1, 82.14)7.3 (−64.78, 81.74)2.13 (−1.93, 6.51)5.24 (−5.29, 15.93)0.03 (−6.19, 6.5)Other therapies
11.73 (−60.44, 86.28)11.21 (−61.13, 85.78)6.04 (−0.56, 12.9)9.15 (−2.52, 21.09)3.94 (−4.18, 12.3)3.91 (−1.36, 9.16)HT
−0.64 (−4.1, 2.83)−1.16 (−4.19, 1.81)−6.33 (−80.56, 65.69)−3.22 (−77.68, 69.63)−8.43 (−82.57, 63.74)−8.46 (−82.86, 63.46)−12.37 (−86.86, 59.93)No treatment
5.67 (−66.27, 79.88)5.15 (−66.85, 79.47)−0.02 (−2.65, 2.61)−2.12 (−7.56, 3.3)−1.54 (−5.08, 2)−2.15 (−5.55, 0.98)−6.06 (−12.38, 0.03)6.31 (−65.74, 80.62)Placebo/sham

Hot flash score

Lifestyle changes
−7.01 (−17.45, 3.66)Mind-body techniques
0.81 (−14.34, 15.87)7.82 (−5.87, 21.2)Dietary/supplements
4.76 (−11.83, 21.44)11.77 (−3.64, 26.98)3.95 (−5.19, 13.07)Other medications
0.08 (−12.2, 12.27)7.09 (−3.43, 17.37)−0.73 (−9.43, 8.13)−4.68 (−15.97, 6.6)Other therapies
−11.28 (−20.09, −2.52)−4.28 (−10.28, 1.42)−12.09 (−24.32, 0.08)−16.05 (−30.2, −1.99)−11.37 (−19.96,−2.87)No treatment
0.98 (−13.66, 15.58)7.99 (−5.03, 20.8)0.17 (−3.8, 4.16)−3.78 (−11.99, 4.43)0.9 (−6.98, 8.71)12.27 (0.78, 23.76)Placebo/sham

Statistically significant difference between two therapies.