Dipteran Carboxymethyl Chitosan as an Inexhaustible Derivative with a Potential Antiproliferative Activity in Hepatocellular Carcinoma Cells

Figure 3

Effects of carboxymethyl chitosan (CM-Ch) on the viability of HepG2 cells. Cells were treated with CM-Ch (1–1200 µg/mL) for 48 h. Controls were treated with DMSO only. (a) CM-Ch reduced HepG2 cell viability. (b) Semilogarithmic plotting of HepG2 cell viability at increasing CM-Ch concentrations was used to calculate IC₅₀. Ca-CM-Ch, Chrysomya albiceps CM-Ch; Sa-CM-Ch, Sarcophaga aegyptiaca CM-Ch; sy-CM-Ch, CM-Ch of commercial chitosan. Data (n = 3) were presented as means ± SEM. value was calculated vs. control cells: , , , and .

(a)

(b)