YQFM Alleviates Side Effects Caused by Dasatinib through the ROCK/MLC Pathway in Mice

Figure 1

Effect of YQFM on intestinal blood flow and histopathological changes of intestinal sections in mice with Dasatinib. YQFM (0.336, 0.672, 1.342 g/kg, i.p.) was injected intraperitoneally 1 h before being administered with dasatinib (70 mg/kg for 3 d, i.p.). (a) The representative images of intestinal blood flow in different groups. The magnitude of IBF is represented by different colors, with blue to red denoting low to high. (b) Quantitative analysis of IBF in different groups. Data are expressed as the mean ± SD, n = 6. vs. control group; vs. model group. (c) Hematoxylin-eosin-stained slides of mouse intestinal sections in different groups were examined under a light microscope, and representative stained sections showed that YQFM improves Dasatinib-induced bleeding. Scale bar = 50 μm. n = 3.

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