Study on Intervention Mechanism of Yiqi Huayu Jiedu Decoction on ARDS Based on Network Pharmacology

Table 3

Information on 61 key hub targets.

Uniprot ID	Gene symbol	Target type	Degree	Betweenness	Closeness
P05771	PRKCB	Putative drug target	35	0.00264685	0.56704981
P25786	PSMA1	Putative drug target	36	0.00300257	0.5648855
P06400	RB1	Known disease target	37	0.00253187	0.57142857
Q92769	HDAC2	Putative drug target	38	0.00336775	0.56923077
P63208	SKP1	Putative drug target	38	0.00245534	0.57142857
Q99460	PSMD1	Putative drug target	39	0.00248828	0.57364341
O60566	BUB1B	Known disease target	41	0.00549867	0.56704981
P62873	GNB1	Putative drug target	41	0.00718391	0.56923077
P22681	CBL	Known disease target	42	0.00342413	0.578125
P25963	NFKBIA	Putative drug target	42	0.00433339	0.578125
P04150	NR3C1	Putative drug target	43	0.00468953	0.58498024
P51692	STAT5B	Putative drug target	43	0.00325874	0.58039216
O14818	PSMA7	Putative drug target	43	0.00316088	0.58039216
Q05655	PRKCD	Putative drug target	44	0.00449992	0.58730159
P31751	AKT2	Known disease target	44	0.00270419	0.58730159
P61073	CXCR4	Putative drug target	45	0.00558369	0.58498024
P37231	PPARG	Common target	45	0.00371233	0.58498024
Q13485	SMAD4	Known disease target	47	0.00371397	0.58964143
Q92793	CREBBP	Known disease target	47	0.00699241	0.592
P60709	ACTB	Known disease target	48	0.00650353	0.59677419
P63000	RAC1	Putative drug target	48	0.00516601	0.59677419
Q14738	PPP2R5D	Known disease target	49	0.00893634	0.59677419
P35570	IRS1	Putative drug target	49	0.00452074	0.59919028
P17612	PRKACA	Putative drug target	50	0.01349606	0.60162602
P11802	CDK4	Known disease target	50	0.00628716	0.60162602
P11142	HSPA8	Putative drug target	50	0.01720136	0.60162602
P06239	LCK	Putative drug target	53	0.00312328	0.6090535
P00519	ABL1	Putative drug target	53	0.00590445	0.60655738
Q16665	HIF1A	Putative drug target	53	0.00718986	0.6090535
P06241	FYN	Putative drug target	53	0.00504871	0.6090535
P10275	AR	Putative drug target	54	0.0067063	0.61157025
P21359	NF1	Known disease target	54	0.00762371	0.6090535
P04049	RAF1	Known disease target	55	0.00496974	0.61410788
Q06124	PTPN11	Common target	56	0.00363149	0.61666667
Q02750	MAP2K1	Known disease target	57	0.0043254	0.61924686
P62714	PPP2CB	Putative drug target	57	0.01088017	0.61924686
P19838	NFKB1	Putative drug target	57	0.00880836	0.61666667
P61586	RHOA	Putative drug target	58	0.00571048	0.62184874
P01100	FOS	Known disease target	58	0.00710084	0.61924686
Q09472	EP300	Known disease target	59	0.0174571	0.62447257
O60674	JAK2	Known disease target	60	0.00538805	0.62711864
P01111	NRAS	Known disease target	62	0.00549342	0.63247863
P46531	NOTCH1	Known disease target	63	0.00726887	0.63247863
P27986	PIK3R1	Common target	65	0.00815513	0.64069264
Q04206	RELA	Putative drug target	65	0.01465454	0.64069264
P60953	CDC42	Putative drug target	69	0.01943588	0.65198238
P05412	JUN	Putative drug target	69	0.01511756	0.65198238
P30153	PPP2R1A	Known disease target	71	0.02557709	0.65777778
P42336	PIK3CA	Known disease target	71	0.01292212	0.65777778
P67775	PPP2CA	Putative drug target	73	0.0246169	0.66367713
P01133	EGF	Known disease target	77	0.01462345	0.67579909
P01308	INS	Common target	77	0.0175801	0.67579909
P07900	HSP90AA1	Putative drug target	77	0.02388431	0.67579909
P01116	KRAS	Common target	81	0.01319493	0.68837209
P12931	SRC	Putative drug target	85	0.01745904	0.7014218
P28482	MAPK1	Common target	86	0.02512912	0.7047619
P60484	PTEN	Known disease target	87	0.0220011	0.70813397
P01112	HRAS	Known disease target	87	0.01721804	0.70813397
P35222	CTNNB1	Known disease target	91	0.02966048	0.72195122
P31749	AKT1	Common target	95	0.03102752	0.73631841
P04637	TP53	Putative drug target	105	0.05675909	0.77486911