Systems Pharmacology-Dissection of the Molecular Mechanisms of Dragon’s Blood in Improving Ischemic Stroke Prognosis

Figure 3

Metascape pathway and process enrichment analysis. (a) The top 20 clusters with their representative enriched terms (one per cluster), for each given gene list, pathway, and process enrichment analysis are carried out with the following ontology sources: KEGG pathway, GO biological processes, Reactome gene sets, canonical pathways, and CORUM. All genes in the genome are used as the enrichment background. Terms with a value < 0.01, a minimum count of 3, and an enrichment factor >1.5. (b) To further capture the relationships between the terms, a subset of enriched terms are selected and rendered as a network plot, where terms with a similarity > 0.3 are connected by edges. We select the terms with the best values from each of the 20 clusters, with the constraint that there are no more than 15 terms per cluster and no more than 250 terms in total. The network is visualized using Cytoscape, where each node represents an enriched term and is colored by cluster ID.

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