Effects of Aqueous and Methanolic Extracts of Stem Bark of Alstonia boonei De Wild. (Apocynaceae) on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Wistar Rats

Table 4

Effects of the aqueous and methanol stem-bark extracts of A. boonei on colon, liver, and spleen mass in DSS-induced colitis in rats.

Treatment	Dose (mg/kg)	Mass (g)
		Colon	Liver	Spleen
Normal control	—	176 ± 0,09	5.43 ± 0.10	0,66 ± 0,06
DMSO (5 %) + PBS	—	1,42 ± 0,05	4,87 ± 0,09	0,55 ± 0,02
Prednisolone	4	1,67 ± 0,05	5,08 ± 0,49	0,51 ± 0,01
Aqueous extract	125	1,65 ± 0,07	5,60 ± 0,52	0,64 ± 0,05
	250	1,43 ± 0,12	5,01 ± 0,32	0,64 ± 0,02
Methanol extract	125	1,45 ± 0,08	5,32 ± 0,21	0,64 ± 0,04
	250	1,60 ± 0,07	5,61 ± 0,24	0,66 ± 0,03

Values are expressed as mean ± SEM for six animals and analyzed by one-way ANOVA followed by Tukey post hoc test.