Electroacupuncture Inhibits the Activity of Astrocytes in Spinal Cord in Rats with Visceral Hypersensitivity by Inhibiting P2Y1 Receptor-Mediated MAPK/ERK Signaling Pathway

<div>Experimental flow chart and the inhibitory effect of FCA on visceral hypersensitivity. (a) Experimental flow chart: neonatal SD rats were administered an intracolonic dose of 5% acetic acid for induction of visceral hypersensitivity of IBS. EA and drug intervention were conducted at the beginning of week 7 and behavioral scores and molecular detection were conducted at the end of week 7. (b)–(e) AWRs of visceral hypersensitivity under stimulation of 20, 40, 60, and 80 mmHg CRD. Normal (n = 8), Model (n = 8), EA (n = 8), and FCA (n = 8).</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 1

Figure 1: Electroacupuncture Inhibits the Activity of Astrocytes in Spinal Cord in Rats with Visceral Hypersensitivity by Inhibiting P2Y1 Receptor-Mediated MAPK/ERK Signaling Pathway

Figure 1 | Electroacupuncture Inhibits the Activity of Astrocytes in Spinal Cord in Rats with Visceral Hypersensitivity by Inhibiting P2Y1 Receptor-Mediated MAPK/ERK Signaling Pathway 