Evidence-Based Complementary and Alternative Medicine

Research Article

Screening for Anti-Influenza Actives of Prefractionated Traditional Chinese Medicines

Table 1

Selectivity indices assay of 10 candidate hits.


TCMs and positive control	Botanical extracts	IC₅₀ (μg/mL)^a	CC₅₀ (μg/mL)^b	SI^c

Areca catechu L.	n-Butanol fraction	1.08	50.73	46.97
Areca catechu L.	Water fraction	1.27	101.2	79.69
Glycyrrhizin	Cyclohexane fraction	2.12	21.27	10.03
Glycyrrhizin	Ethyl acetate fraction	6.45	48.5	7.52
Cinnamon	n-Butanol fraction	1.94	190.9	98.40
Cinnamon	Water fraction	1.95	127.8	65.54
Tripterygium wilfordii	n-Butanol fraction	1.81	74.43	41.12
Spatholobus suberectus	n-Butanol fraction	1.99	102.3	51.41
Polygonum cuspidatum	n-Butanol fraction	1.56	136.2	87.31
Magnolia officinalis	Ethyl acetate fraction	3.55	42.94	12.10
BXA	—	0.0015	>0.097	>65

a: IC50, 50% inhibitory concentration; b: CC50, 50% cytotoxicity concentration; c: SI, selectivity index, SI= CC50/IC50. Baloxavir acid as the positive control. The inhibitory and cytotoxicity effects were analyzed using GraphPad Prism 5.