Pharmacokinetic Herb-Drug Interaction between Hibiscus sabdariffa Calyces Aqueous Extract and Captopril in Rats

Table 5

90% CI for geometric mean ratios of AUC_0−t, AUC_0−∞, and C_max.

Parameter	Geometric mean		Geometric mean ratio	90% confidence interval^+
	Group I	Group II
AUC0−t (ng h/mL)	907.1936	158.3434	0.1745	0.1254–0.2429
AUC0−∞ (ng h/mL)	937.3462	162.5549	0.1734	0.1232–0.2442
Cmax (ng/mL)	260.6754	55.2459	0.2119	0.1337–0.3359

Group I, captopril alone; group II, coadministration with Hibiscus sabdariffa extract; AUC, area under the curve; Cmax, maximum concentration; Group II/group I; ⁺Lower limit/upper limit.