Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats

Figure 3

Microphotography of rat’s prostate stained with Hematoxylin and Eosin (H&E), at 10 X and 40 X magnification. (a) Physiological saline 2 mL/kg. Normal. Cubic cells, not columnar. (b) Prostate tissue with induced cancer. Many layers are observed, cells in mitosis; large number of cells with high-grade prostatic intraepithelial neoplasia (HG-PIN) and low-grade prostatic intraepithelial neoplasia (LG-PIN). (c) Cordia lutea 50 mg/kg, intraepithelial neoplasia of low and somewhat grade is observed. (d) Cordia lutea 250 mg/kg, basically hyperplasia is observed, high- and low-grade foci are not reached. (e) Induced + Cordia lutea 500 mg/kg, hyperplasia is observed; it remains in hyperplasia; it does not reach high-grade or low-grade foci.

(a)

(b)

(c)

(d)

(e)