Metabolomics Analysis of Laparoscopic Surgery Combined with Wuda Granule to Promote Rapid Recovery of Patients with Colorectal Cancer Using UPLC/Q-TOF-MS/MS
Table 3
Identification results of varying ions and their change trend.
No.
Metabolite
VIP
RT (min)
Formula
Adduct
Calculated
Trend
Related pathway
MG/HG
FTG/MG
WDG/MG
1☆
LysoPC (16:0)
11.93
10.11
C24H50O7NP
[M+H]+
496.3398
↑∗∗∗
↓###
↓&&&
Glycerophospholipid metabolism
2
LysoPC (18:1)
9.57
10.29
C26H52O7NP
[M+H]+
522.3554
↑∗∗∗
↓###
↓&&&
Glycerophospholipid metabolism
3☆
LysoPC (18:0)
9.41
11.25
C26H54O7NP
[M+H]+
524.3711
↑∗∗∗
↓###
↓&&&
Glycerophospholipid metabolism
4
LysoPC (18:2)
8.33
9.60
C26H50O7NP
[M+H]+
520.3398
↑∗∗∗
↓###
↓&&&
Glycerophospholipid metabolism
5
LysoPC (22:6)
6.61
9.61
C30H50O7NP
[M+H]+
568.3398
↑∗∗∗
↓##
↓&&&
Glycerophospholipid metabolism
6
LysoPE (16:0)
5.29
9.92
C21H44O7NP
[M+H]+
454.2928
↑∗∗∗
↓###
↓&&&
Glycerophospholipid metabolism
7
11-HETE
3.22
9.75
C20H32O3
[M+H]+
321.2424
↑∗∗∗
↓###
↓&&&
Arachidonic acid metabolism
8☆
Leucine
2.98
1.62
C6H13NO2
[M+H]+
132.1019
↑∗∗∗
↓#
↓&&&
Other
9☆
Glutamine
2.45
0.66
C5H10N2O3
[M+H]+
147.0764
↓∗∗∗
↑###
↑&&&
Alanine, aspartate, and glutamate metabolism
10☆
5-Hydroxytryptamine
2.11
1.28
C10H12N2O
[M+H]+
177.1022
↓∗∗
↑
↑&&&
Tryptophan metabolism
11☆
Tryptophan
2.02
3.59
C11H12N2O2
[M+H]+
205.0972
↓∗∗∗
↑###
↑&&&
Tryptophan metabolism
12
Cystine
1.91
1.59
C6H12N2O4S2
[M+H]+
241.0311
↑∗∗
↓#
↓
Other
13
Thromboxane B2
1.74
4.14
C20H34O6
[M+H]+
371.2428
↓∗∗∗
↑###
↑&&&
Arachidonic acid metabolism
14
LysoPE (22:6)
9.21
9.59
C27H44O7NP
[M–H]–
524.2783
↑∗∗∗
↓###
↓&&&
Glycerophospholipid metabolism
15☆
Arachidonic acid
5.12
12.50
C20H32O2
[M–H]–
303.2331
↑∗∗∗
↓#
↓&&&
Arachidonic acid metabolism
16☆
Pyruvic acid
3.98
0.87
C3H4O3
[M–H]–
87.0088
↑∗∗∗
↓###
↓&&&
Pyruvate metabolism
17☆
α-Linolenic acid
3.16
12.04
C18H30O2
[M–H]–
277.2173
↓∗∗∗
↓
↑&
α-Linolenic acid metabolism
18☆
Palmitic acid
2.64
13.13
C16H32O2
[M–H]–
255.2329
↑∗∗∗
↓##
↓&&
Other
19
9-HODE
2.37
10.21
C18H32O3
[M–H]–
295.2279
↑∗∗∗
↓###
↓&&&
Linoleic acid metabolism
20☆
Histidine
1.85
0.62
C6H9N3O2
[M–H]–
154.0622
↓
↓
↑&&
Histidine metabolism
Note. ☆: confirmed with the reference substances. ↑: the compound is upregulated. ↓: the compound is downregulated. Represents the changes in MG compared with HG, ,,; represents the changes in FTG compared with MG, ,,; and represents the changes in WDG compared with MG, ,,.