Metabolomics Analysis of Laparoscopic Surgery Combined with Wuda Granule to Promote Rapid Recovery of Patients with Colorectal Cancer Using UPLC/Q-TOF-MS/MS

Table 3

Identification results of varying ions and their change trend.

No.	Metabolite	VIP	RT (min)	Formula	Adduct	Calculated	Trend			Related pathway
							MG/HG	FTG/MG	WDG/MG
1☆	LysoPC (16:0)	11.93	10.11	C24H50O7NP	[M+H]^+	496.3398	↑^∗∗∗	↓^###	↓^&&&	Glycerophospholipid metabolism
2	LysoPC (18:1)	9.57	10.29	C26H52O7NP	[M+H]^+	522.3554	↑^∗∗∗	↓^###	↓^&&&	Glycerophospholipid metabolism
3☆	LysoPC (18:0)	9.41	11.25	C26H54O7NP	[M+H]^+	524.3711	↑^∗∗∗	↓^###	↓^&&&	Glycerophospholipid metabolism
4	LysoPC (18:2)	8.33	9.60	C26H50O7NP	[M+H]^+	520.3398	↑^∗∗∗	↓^###	↓^&&&	Glycerophospholipid metabolism
5	LysoPC (22:6)	6.61	9.61	C30H50O7NP	[M+H]^+	568.3398	↑^∗∗∗	↓^##	↓^&&&	Glycerophospholipid metabolism
6	LysoPE (16:0)	5.29	9.92	C21H44O7NP	[M+H]^+	454.2928	↑^∗∗∗	↓^###	↓^&&&	Glycerophospholipid metabolism
7	11-HETE	3.22	9.75	C20H32O3	[M+H]^+	321.2424	↑^∗∗∗	↓^###	↓^&&&	Arachidonic acid metabolism
8☆	Leucine	2.98	1.62	C6H13NO2	[M+H]^+	132.1019	↑^∗∗∗	↓^#	↓^&&&	Other
9☆	Glutamine	2.45	0.66	C5H10N2O3	[M+H]^+	147.0764	↓^∗∗∗	↑^###	↑^&&&	Alanine, aspartate, and glutamate metabolism
10☆	5-Hydroxytryptamine	2.11	1.28	C10H12N2O	[M+H]^+	177.1022	↓^∗∗	↑	↑^&&&	Tryptophan metabolism
11☆	Tryptophan	2.02	3.59	C11H12N2O2	[M+H]^+	205.0972	↓^∗∗∗	↑^###	↑^&&&	Tryptophan metabolism
12	Cystine	1.91	1.59	C6H12N2O4S2	[M+H]^+	241.0311	↑^∗∗	↓^#	↓	Other
13	Thromboxane B2	1.74	4.14	C20H34O6	[M+H]^+	371.2428	↓^∗∗∗	↑^###	↑^&&&	Arachidonic acid metabolism
14	LysoPE (22:6)	9.21	9.59	C27H44O7NP	[M–H]^–	524.2783	↑^∗∗∗	↓^###	↓^&&&	Glycerophospholipid metabolism
15☆	Arachidonic acid	5.12	12.50	C20H32O2	[M–H]^–	303.2331	↑^∗∗∗	↓^#	↓^&&&	Arachidonic acid metabolism
16☆	Pyruvic acid	3.98	0.87	C3H4O3	[M–H]^–	87.0088	↑^∗∗∗	↓^###	↓^&&&	Pyruvate metabolism
17☆	α-Linolenic acid	3.16	12.04	C18H30O2	[M–H]^–	277.2173	↓^∗∗∗	↓	↑^&	α-Linolenic acid metabolism
18☆	Palmitic acid	2.64	13.13	C16H32O2	[M–H]^–	255.2329	↑^∗∗∗	↓^##	↓^&&	Other
19	9-HODE	2.37	10.21	C18H32O3	[M–H]^–	295.2279	↑^∗∗∗	↓^###	↓^&&&	Linoleic acid metabolism
20☆	Histidine	1.85	0.62	C6H9N3O2	[M–H]^–	154.0622	↓	↓	↑^&&	Histidine metabolism

Note. ☆: confirmed with the reference substances. ↑: the compound is upregulated. ↓: the compound is downregulated. Represents the changes in MG compared with HG, , , ; represents the changes in FTG compared with MG, , , ; and represents the changes in WDG compared with MG, , , .