Evidence-Based Complementary and Alternative Medicine / 2020 / Article / Tab 1

Review Article

Efficacy of Lianhua Qingwen Compared with Conventional Drugs in the Treatment of Common Pneumonia and COVID-19 Pneumonia: A Meta-Analysis

Table 1

Main characteristics and quality score of the included studies for common pneumonia and COVID-19 pneumonia.

TypeStudyYearGroupAgeSexEfficacy evaluationAdverse reactionsQuality score
T/CT (M/F)C (M/F)

Common pneumoniaChen2020R5.45 ± 0.55/5.37 ± 0.3852 (26/26)52 (23/29)Curative effect, fever, cough, pulmonary raleGastrointestinal reaction, back pain, cry and scream, headache4
Chen2020I7.81 ± 1.64/7.77 ± 1.5379 (45/37)78 (42/36)Curative effect, fever, coughDiarrhoea, tachycardia, facial redness, headache, rash2
Feng2020R44.5 ± 10.7/43.6 ± 10.137 (19/18)37 (20/17)Curative effect, healing periodNot reported4
Wang2019R5.55 ± 1.68/5.28 ± 1.5380 (44/36)80 (42/38)Curative effectNot reported4
Lin2019R7.33 ± 2.42/4.34 ± 1.4153 (30/23)50 (28/25)Curative effect, fever, cough, sputum, pulmonary rale, healing periodNot reported4
Sun2019I51.06 ± 5.92/50.17 ± 5.6841 (28/13)41 (27/14)Curative effect, cough, fever, pulmonary raleNausea, vomiting, diarrhoea2
Xia2019H19.5 ± 2.15555Curative effect, cough, fever, Healing period, pulmonary raleVomiting, rash, dizziness2
Hu2018R43.4 ± 4.8/44.7 ± 4.152 (37/15)52 (36/16)Curative effect, cough, fever, pulmonary rale, healing periodGastrointestinal reaction, loss of appetite, vomiting4
Lv2018R48.42 ± 7.59/48.61 ± 7.7360 (29/31)60 (27/33)Curative effect, cough, fever, pulmonary raleStomach ache, nausea, rash4
Chen2018R6.44 ± 3.505958Fever, cough, pulmonary rale, healing periodNo adverse reaction4
Zhang2018R69.4 ± 2.1/69.2 ± 2.039 (24/15)39 (23/16)Curative effect, cough, sputum, pulmonary raleIncreased gamma glutamyl aminotransferase, hypotension, edema3
Zhang2018R46.81 ± 9.22/46.91 ± 9.3460 (32/28)60 (33/27)Curative effect, fever, cough, pulmonary raleDiarrhoea, rash, elevated aspartate transferase3
Liu2017R40.34 ± 9.23/42.13 ± 8.1853 (30/23)53 (32/21)Curative effect, fever, cough, pulmonary raleNo adverse reaction3
Han2017I5.24 ± 1.03/6.27 ± 0.9862 (31/31)62 (33/29)Pulmonary rale, cough, fever, healing periodNot reported2
Yang2016R29.20 ± 5.103822Curative effect, fever, cough, pulmonary imaging improvement, healing periodGastrointestinal reaction3
Wang2015R61–75/59–743434Curative effect, fever, cough, pulmonary raleLoss of appetite, skin itch, dizziness3
Tu2015R5.3 ± 1.1/5.1 ± 1.350 (30/20)50 (28/22)Fever, cough, pulmonary rale, healing periodNot reported3
Xu2015R35.6 ± 12.8/34.8 ± 13.238 (18/20)30 (14/16)Fever, healing periodNo specific type3
Meng2015R50.7 ± 3.4/51.4 ± 4.220 (12/8)18 (10/8)Curative effect, fever, coughNausea, rash4
Zhu2015R47.0 ± 3.0/48.5 ± 3.531 (23/8)31 (21/10)Curative effect, fever, cough, sputum, pulmonary imaging improvementRash, leukopenia, gastrointestinal reaction4
Li2014R45.3 ± 1.3/44.6 ± 1.243 (27/16)43 (25/18Curative effect, cough, fever, pulmonary imaging improvement, healing periodNo adverse reaction3
Li2014R45.4/44.325 (13/12)24 (12/12)Curative effectNo adverse reaction3
Jiang2014R18–6560 (32/28)60 (38/22)Curative effect, fever, cough, pulmonary rale, pulmonary imaging improvementDiarrhoea3
Liu2014R61.82 ± 18.50/59.23 ± 13.5052 (30/22)52 (32/20)Curative effect, fever, cough, pulmonary rale, pulmonary imaging improvementNo adverse reaction3
Gao2014R48.2 ± 6.7/51.3 ± 4.860 (34/26)60 (33/27)Curative effect, fever, cough, pulmonary imaging improvement, healing periodRash, white blood cell index returned to normal, gastrointestinal reaction3
Zou2014R76.5 ± 5.2/77.2 ± 5.930 (18/12)30 (20/10)Curative effect, fever, cough, pulmonary rale, sputumNausea, vomiting3
Dong2014R71.64 ± 11.73/72.58 ± 10.6940 (21/19)42 (24/18)Curative effect, fever, cough, sputumNo adverse reaction3
Wang2014R36.3 ± 7.50/35.6 ± 7.4040 (26/14)38 (24/14)Curative effect, feverNo adverse reaction3
Wang2014R3 to 1530 (19/11)30 (17/13)Curative effect, fever, cough, pulmonary raleNo adverse reaction3
Zhou2014R35.3 ± 7.60/30.10 ± 7.5046 (26/20)41 (19/22)Curative effect, feverNo adverse reaction3
Wang2013R18 to 655050Curative effect, fever, cough, pulmonary imaging improvement, healing periodNot reported3
Chen2013R71 ± 8.676 (44/32)76 (42/34)Curative effect, fever, cough, pulmonary rale, healing periodNausea, diarrhoea, rash3
Peng2013R33.6 ± 11.2/32.8 ± 10.130 (16/14)30 (15/15)Curative effectNo adverse reaction5
Zhong2013R35.3 ± 7.60/30.10 ± 7.5038 (20/18)32 (17/15)Curative effectNo adverse reaction3
Xu2012R28.30 ± 6.80/29.20 ± 6.5032 (18/14)30 (16/14)Curative effect, feverNo adverse reaction3
COVID-19 pneumoniaCheng2020I55.5 ± 12.3/55.8 ± 11.651 (26/25)51 (27/24)Fever, cough, fatigue, muscle pain, Sputum, shortness of breath, chest tightness, pulmonary imaging improvement, breathlessness, nausea, loss of appetiteNot reported2
Hu2020R50.4 ± 15.2/51.8 ± 14.8142 (79/63)142 (71/71)Curative effect, pulmonary imaging improvement, conversion of severe casesAbnormal liver function, renal insufficiency, headache, nausea, vomiting, diarrhoea, loss of appetite5
Lv2020I59.1 ± 16.56/60.2 ± 17.0163 (28/35)38 (18/20)Fever, cough, fatigue, muscle pain, sputum, sore throat, shortness of breath, chest tightness, breathlessness, headache, nausea, loss of appetite, diarrhoeaNo adverse reaction2
Shi2020I47.94 ± 14.46/46.72 ± 17.4049 (26/23)18 (10/8)Curative effect, fever, healing period, pulmonary imaging improvement, conversion of severe casesNot reported2
Xia2020I54.18 ± 13.08/53.67 ± 12.7034 (17/17)18 (6/12)Curative effect, healing period, pulmonary imaging improvement, conversion of severe casesNo adverse reaction2
Yao2020I57.1 ± 14.0/62.4 ± 12.321 (16/5)21 (12/9)Fever, cough, fatigue, muscle pain, sputum, sore throat, shortness of breath, chest tightness, breathlessness, headache, nausea, loss of appetite, diarrhoeaNot reported2
Yu2020R48.27 ± 9.56/47.25 ± 8.67147 (82/65)147 (89/59)Curative effect, pulmonary imaging improvement, conversion of severe casesNo adverse reaction4

R, randomization; I, intervention; H, hospitalization order; S, subject; T, treatment group; C, control group; M, male; F, female.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.