Oral Chinese Herbal Medicine as Prophylactic Treatment for Episodic Migraine in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Table 5

Summary of adverse events.

Adverse events	Number and severity reported by the CHM group	Number and severity reported by the flunarizine group
Gastrointestinal symptoms	11 mild	12 mild
Drowsiness	5 mild	7 mild
Fatigue	6 mild	11 mild
Dizziness	5 mild	2 mild
Insomnia	3 mild	3 mild
Irregular menstruation	3 mild	0
Decrease of platelet	1 mild	0
Acne	1 mild	0
Extrapyramidal symptoms	0	5 mild
Weight gain	0	9 mild
Liver dysfunction	0	1 moderate
Dry mouth	0	1 mild
All adverse events reported in treatment and follow-up phases	35 mild	50 mild and 1 moderate

Note: CHM, Chinese herbal medicine.