Neuroprotective Activity of Methanolic Extract of <i>Lysimachia christinae</i> against Glutamate Toxicity in HT22 Cell and Its Protective Mechanisms

<div>The mitochondrial membrane potential level of <i>L. christinae</i> against glutamate toxicity in HT22 cells. Cell was pretreated with 10, 20, and 50 <i>μ</i>g/ml of <i>L. christinae</i> and trolox (30 <i>μ</i>M). Then, 2.5 mM glutamate was treated for 30 <i>μ</i>l after 1 h. 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-12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,49.05,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,55.29,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,61.53,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> compared to glutamate-injured cells (ANOVA).</div>

Evidence-Based Complementary and Alternative Medicine

fig4

Figure 4

Figure 4: Neuroprotective Activity of Methanolic Extract of <i>Lysimachia christinae</i> against Glutamate Toxicity in HT22 Cell and Its Protective Mechanisms 

Figure 4 | Neuroprotective Activity of Methanolic Extract of Lysimachia christinae against Glutamate Toxicity in HT22 Cell and Its Protective Mechanisms 