Evaluation of the Antimalarial Activity of the Hydroalcoholic Extract of Leaf of Leonotis ocymifolia (Burm. f.) Iwarsson (Lamiaceae) against Plasmodium berghei in Mice

Table 1

Antimalarial activity test of the hydroalcoholic extracts of leaf of Leonotis ocymifolia against P. berghei in the four-day suppressive test.

Treatment (mg/kg)	Parasitemia (%)	Suppression (%)	MSTSEM (days)
CON	38.794.1	—	6.881.55
HA 100 mg/kg	37.492.81	6.5^d3	6.751.49
HA 200 mg/kg	29.563.06	23.33^a3	7.251.39
HA 400 mg/kg	24.463.30	36.55^a3c3d2	8.881.55^a1c1
HA 800 mg/kg	22.593.21	41.4^a3c3d3	8.750.31^a1c1
CQ 25 mg/kg	0000.00	100^a3c3d3e3f3	28.00 ± 0.00^a3c3d3e3f3

Data are expressed as mean ± SEM (n = 8); ^acompared to negative control; ^bcompared to CQ 25 mg/kg; ^ccompared to 100 mg/skg; ^dcompared to 200 mg/kg; ^ecompared to 400 mg/kg; ^fcompared to 800 mg/kg:  < 0.05,  < 0.01, and  < 0.001; HA, hydroalcoholic; negative controls received 2% Tween 80 in water; CON, negative control; CQ, chloroquine.