Evaluation of the Antimalarial Activity of the Hydroalcoholic Extract of Leaf of Leonotis ocymifolia (Burm. f.) Iwarsson (Lamiaceae) against Plasmodium berghei in Mice

Table 5

Antimalarial activity test of the hydroalcoholic extracts of leaf of Leonotis ocymifolia against P. berghei in prophylactic test.

Treatment (mg/kg)	Parasitemia (%)	Suppression (%)	MSTSEM (days)
CON	20.773.12	—	6.621.06
HA 200 mg/kg	17.440.57	16.01^a3	7.251.39
HA 400 mg/kg	13.840.55	25.76^a3d3	7.381.06
HA 800 mg/kg	13.170.35	29.36^a3d3e1	7.251.28
CQ25 mg/kg	0.110.15	99.40^a3d3e3f3	8.700.64^a1

Data are expressed as mean SEM (n = 8); analysis was performed with one-way ANOVA followed by the Tukey test; ^acompared to negative control; ^bcompared to CQ 25 mg/kg; ^dcompared to 200 mg/kg; ^ecompared to 400 mg/kg; ^fcompared to 800 mg/kg:  < 0.05,  < 0.01, and  < 0.001; HA, hydroalcoholic; negative controls received 2% Tween 80 in water; CON, negative control; CQ, chloroquine.