Evaluation of the Antimalarial Activity of the Hydroalcoholic Extract of Leaf of Leonotis ocymifolia (Burm. f.) Iwarsson (Lamiaceae) against Plasmodium berghei in Mice
Table 6
Body weight, rectal temperature, and packed cell volume of P. berghei-infected Swiss albino group treated with hydroalcoholic extract of leaf of Leonotis ocymifolia in prophylactic test.
Treatment (mg/kg)
Body weight
Temperature
Packed cell volume (PCV)
Day 0
Day 3
Change (%)
Day 0
Day 3
Change (%)
Day 0
Day 3
Change (%)
CON
36.980.45
35.10.44
−5.14
36.980.45
35.060.46
−5.24
54.943.84
49.704.20
−5.24
HA 200 mg/kg
37.030.5
35.540.47
−4.05
37.030.5
35.480.57
−4.18
56.294.72
53.136.60
−3.15
HA 400 mg/kg
36.681.16
35.691.11
−2.71
36.761.13
35.511.18
−3.34
53.961.83
52.531.54
−1.44
HA 800 mg/kg
37.340.51
36.351.59
−2.65
37.310.55
36.111.78
−3.24
54.551.36
52.121.34
−2.43
CQ 25 mg/kg
36.860.61
36.740.71
0.34a3d2
36.860.61
36.740.713
−0.33a2d1
52.452.79
52.203.19
−0.25a2d2
Data are expressed as mean ± SEM (n = 8); acompared to negative control; bcompared to CQ 25 mg/kg: < 0.05, < 0.01, and < 0.001; HA, hydroalcoholic; CON, negative control; CQ, chloroquine.
