Research Article
The Antiemetic Effect of Xiao-Ban-Xia-Tang Formula against Cisplatin-Induced Emesis is Mediated through Inhibition of NLRP3 Inflammasome Activation in a Rat Pica Model
Figure 5
Effect of XBXT and ondansetron on NLRP3 inflammasome protein expression induced by cisplatin in the rat antrum (n = 3). (a–h) Western blot analysis of NLRP3, ASC, caspase-1, and IL-1β in the antrum, and band densities were converted to a bar graph. (i) Representative photograph of caspase-1 with immunofluorescence staining of the antrum, and (j) quantitative data showing the mean fluorescence intensity of caspase-1. Photographs were observed under a fluorescence microscope at 200 ×magnification (scale bar = 100 μm). Data represent means ± SEM. The data were analyzed for significant differences using a one-way ANOVA followed by Tukey’s post hoc test. , , and vs the cisplatin model group. Nor, normal control group; Cis, cisplatin model group; Ond, ondansetron treatment group; XBXT, XBXT treatment group.
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