The Antiemetic Effect of Xiao-Ban-Xia-Tang Formula against Cisplatin-Induced Emesis is Mediated through Inhibition of NLRP3 Inflammasome Activation in a Rat Pica Model

Figure 7

Effect of XBXT and ondansetron on NLRP3 inflammasome formation induced by cisplatin in the rat antrum (n = 3). (a) The colocalization images of NLRP3 (red)/ASC (green), (b) the colocalization images of NLRP3 (red)/caspase-1 (green), (c) summarized data showing the colocalization efficiency (Pearson’s correlation coefficient) of NLRP3 with ASC, and (d) summarized data showing the colocalization efficiency (Pearson’s correlation coefficient) of NLRP3 with caspase-1. Nuclei were stained with DAPI (blue). Photographs were observed under a fluorescence microscope at 200 × magnification (scale bar = 100 μm). Data represent means ± SEM. The data were analyzed for significant differences using a one-way ANOVA followed by Tukey’s post hoc test. , , and vs the cisplatin model group. Nor, normal control group; Cis, cisplatin model group; Ond, ondansetron treatment group; XBXT, XBXT treatment group.

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