Neuroprotective Effects of D-(-)-Quinic Acid on Aluminum Chloride-Induced Dementia in Rats

Table 1

Effect of D-(-)-quinic acid on aluminum chloride-induced dementia in rats using the Morris water maze.

Groups/treatments	ELT (sec)
	5th day	16th day	26th day	36th day
I (control): 0.9% NaCl (5 ml/kg, p.o.)	3.77 ± 0.09	4.27 ± 0.21	4.75 ± 0.17	5.32 ± 0.42
II (inducer): AlCl3 (175 mg/kg, p.o.)	3.76 ± 0.11	9.66 ± 0.34	13.61 ± 0.23	17.85 ± 2.14
II (standard): AlCl3 (175 mg/kg, p.o.) + rivastigmine (2.5 mg/kg)	3.69 ± 0.32	8.98 ± 0.52	11.44 ± 0.24	6.82 ± 0.67
IV (test A): AlCl3 (175 mg/kg, p.o.) + D-(-)-quinic acid (200 mg/kg, p.o.)	3.81 ± 0.57	9.15 ± 0.26	10.27 ± 0.11	9.25 ± 0.54^a
V (test B): AlCl3 (175 mg/kg, p.o.) + D-(-)-quinic acid (400 mg/kg, p.o.)	3.77 ± 0.37	9.34 ± 0.17	11.04 ± 0.32	8.72 ± 0.67^a

Data are presented as mean ± SEM values, n = 6. Data were analyzed by one-way ANOVA followed by the Tukey -Kramer multiple comparison test and the significance of results showed as ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, ^nsp > 0.05 when compared with the normal control. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 when compared with the normal control, 1, ^awhen compared with the inducer, and ^bwhen compared with the standard.