Neuroprotective Effects of D-(-)-Quinic Acid on Aluminum Chloride-Induced Dementia in Rats

Table 2

Effect of D-(-)-quinic acid on aluminum chloride-induced dementia in rats using the Morris water maze.

Groups/treatments	TT (sec)
	5th day	16th day	26th day	36th day
I (control): 0.9% NaCl (5 ml/kg, p.o.)	26.18 ± 0.11	28.19 ± 0.10	27.24 ± 0.092]	30.34 ± 0.35
II (inducer): AlCl3 (175 mg/kg, p.o.)	24.11 ± 0.08	17.95 ± 0.08	15.42 ± 0.18	12.34 ± 0.36
III (standard): AlCl3 (175 mg/kg, p.o.) + rivastigmine (2.5 mg/kg, p.o.)	22.62 ± 0.09	19.25 ± 0.17	21.75 ± 0.25	23.97 ± 0.16^a
IV (test A): AlCl3 (175 mg/kg, p.o.) + D-(-)-quinic acid (200 mg/kg, p.o.)	23.18 ± 0.13	18.81 ± 0.07	18.43 ± 0.17	21.76 ± 0.25^a
V (test B): AlCl3 (175 mg/kg, p.o.) + D-(-)-quinic acid (400 mg/kg, p.o.)	24.70 ± 0.25	20.54 ± 0.13	21.70 ± 0.09	26.75 ± 0.29^a^b ns

Data are presented as mean ± SEM values, n = 6. Data were analyzed by one-way ANOVA followed by the Tukey -Kramer multiple comparison test and the significance of results showed as ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, ^nsp > 0.05 when compared with the normal control. ^#p < 0.05, ^##p < 0.01 , ^###p < 0.001 when compared with the normal control, 1, ^awhen compared with the inducer, and ^bwhen compared with the standard.