Neuroprotective Effects of D-(-)-Quinic Acid on Aluminum Chloride-Induced Dementia in Rats

Table 3

Effect of D-(-)-quinic acid on aluminum chloride-induced dementia in rats as indicated using an actophotometer.

Groups/treatments	LA (count/10 min) on 5th day	LA (count/10 min) on 16th day	LA (count/10 min) on 26th day	LA (count/10 min) on 36th day
I (control): 0.9% NaCl (5 ml/kg, p.o.)	150.11 ± 1.24	159.34 ± 0.93	155.43 ± 0.91	151.22 ± 1.68
II (inducer): AlCl3 (175 mg/kg, p.o.)	163.47 ± 2.37	89.58 ± 0.63	82.10 ± 1.01	76.82 ± 1.85
III (std.): AlCl3 (175 mg/kg, p.o.)+ rivastigmine (2.5 mg/kg)	145.72 ± 1.03	86.17 ± 0.36	83.09 ± 0.89	143.09 ± 2.46
IV (test A): AlCl3 (175 mg/kg, p.o.) + D-(-)-quinic acid (200 mg/kg, p.o.)	147.29 ± 0.82	84.90 ± 0.45	82.59 ± 0.79	100.49 ± 1.93^a^b
V (test B): AlCl3 (175 mg/kg, p.o.) + D-(-)-quinic acid (400 mg/kg, p.o.)	159.98 ± 1.46	83.75 ± 0.72	83.30 ± 0.67	123.39 ± 2.14^a^b

Data are presented as mean ± SEM values, n = 6. Data were analyzed by one-way ANOVA followed by the Tukey–Kramer multiple comparison test , , , ^ns when compared with the normal control, , , , ^awhen compared with the inducer, and ^bwhen compared with the standard.