Neuroprotective Effects of D-(-)-Quinic Acid on Aluminum Chloride-Induced Dementia in Rats

Table 4

Effect of D-(-)-quinic acid on aluminum chloride-induced dementia in rats as indicated by biochemical parameters.

Groups/treatments	AChE (nM/L/gm of tissue)	GSH (nM/mg of protein)	Catalase (µM of H2O2 decomposed/min/mg of protein)	SOD (units/mg of protein)	TBARS (nM/mg of protein)	Nitrite (nM/mg of protein)
I (control): 0.9% NaCl (5 ml/kg, p.o.)	1.39 ± 0.09	2.50 ± 0.10	1.87 ± 0.15	4.77 ± 0.20	0.57 ± 0.10	1.87 ± 0.22
II (inducer): AlCl3 (175 mg/kg, p.o.)	3.50 ± 0.15	0.90 ± 0.04	0.64 ± 0.16	1.00 ± 0.10	1.38 ± 0.05	3.79 ± 0.20
III (standard): AlCl3 (175 mg/kg, p.o.) + rivastigmine (2.5 mg/kg, p.o.)	1.78 ± 0.15	2.09 ± 0.05	1.61 ± 0.19	4.20 ± 0.22	0.61 ± 0.05	2.52 ± 0.15
IV (test A): AlCl3 (175 mg/kg, p.o.) + D-(-)-quinic acid (200 mg/kg, p.o.)	2.73 ± 0.07^a	1.87 ± 0.15^a	0.81 ± 0.22a ns b	3.21 ± 0.17^a	1.19 ± 0.03^a	3.21 ± 0.17^a
V (test B): AlCl3 (175 mg/kg, p.o.) + D-(-)-quinic acid (400 mg/kg, p.o.)	2.22 ± 0.15^a b	1.96 ± 0.15^a^b	1.024 ± 0.13^a^b ns	3.99 ± 0.12^a	0.88 ± 0.04^a	3.03 ± 0.10^a^b

Data are presented as mean ± SEM values, n = 6. Data were analyzed by one-way ANOVA followed by the Tukey–Kramer multiple comparison test , , , ^ns when compared with the normal control, , , , ^awhen compared with the inducer, and ^bwhen compared with the standard.