Neuroprotective Effects of D-(-)-Quinic Acid on Aluminum Chloride-Induced Dementia in Rats

Table 5

Effect of D-(-)-quinic acid on monoamine oxidase (MAO) level in the rat brain.

Groups/treatments	MAO-A (nmol/mg of protein)	MAO-A inhibition (%)	MAO-B (nmol/mg of protein)	MAO-B
Inhibition (%)
I (control): 0.9% NaCl (5 ml/kg, p.o.)	29.5 ± 1.42		25.4 ± 1.48
II (inducer): AlCl3 (175 mg/kg, p.o.)	39.8 ± 1.28	0.00	34.5 ± 0.61	0.00
III (std.): AlCl3 (175 mg/kg, p.o.) + rivastigmine (2.5 mg/kg)	34.5 ± 0.92 ^ns	14	30.6 ± 1.81 ^ns	12.4
IV (test A): AlCl3 (175 mg/kg, p.o.) + D-(-)-quinic acid (200 mg/kg, p.o.)	32.5 ± 1.12	18.4	28.3 ± 0.51	17.8
V (test B): AlCl3 (175 mg/kg, p.o.) + D-(-)-quinic acid (400 mg/kg, p.o.)	30.1 ± 1.41	23.7	26.5 ± 1.41	23.2

Data are presented as mean ± SEM values, n = 6. Data were analyzed by one-way ANOVA followed by the Tukey -Kramer multiple comparison test ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, ns p > 0.05 when compared with the normal control.