Protective Effects and Metabolic Regulatory Mechanisms of Shenyan Fangshuai Recipe on Chronic Kidney Disease in Rats

Table 2

Production changes of differential metabolites which were detected by UPLC-HRMS and screened with Student’s t-test.

No.	Retention-time	Formula	Name	Ratio (model/control)	Ratio (SFR/model)	value (model/control)	value (SFR/model)
1	3.623	C7H15NO3	L-carnitine	0.003537	225.13066	1.089E − 07	3.966E − 13
2	10.951	C4H9NO2S	L-homocysteine	1.4923497	0.4590147	0.00791	0.0011462
3	0.683	C18H32O18	1,4-beta-d-glucan	2.2080128	0.4730602	1.508E − 06	7.271E − 05
4	7.896	C9H7NO	1H-indole-3-carboxaldehyde	1.8008591	0.3787874	6.835E − 05	1.383E − 05
5	7.896	C10H9N	2-aminonaphthalene	1.7888843	0.3995305	2.87E − 05	9.924E − 06
6	8.019	C9H8O3	2-hydroxycinnamic acid	4.102932	0.2163455	2.432E − 07	3.139E − 07
7	4.669	C8H8O5	3,4-dihydroxymandelic acid	1.5635809	0.6384346	1.316E − 07	0.000609
8	4.907	C9H9NO2	3-methyldioxyindole	0.0617987	28.545473	0.0003882	0.0001272
9	7.896	C9H9N	3-methylindole	1.726946	0.3973962	5.069E − 05	9.508E − 06
10	6.06	C3H8NO6P	L-serine	1.4661334	0.6594405	1.218E − 06	0.0028474
11	8.01	C9H11NO3	L-tyrosine	3.0930061	0.2851314	1.762E − 07	2.003E − 07
12	8.019	C7H6O2	4-hydroxybenzaldehyde	4.8105695	0.1788097	2.149E − 07	2.108E − 07
13	11.157	C7H6O3	4-hydroxybenzoic acid	0.1746762	5.7697183	3.787E − 05	2.714E − 09
14	8.978	C7H14N2O6S	5-l-glutamyl-taurine	0.0276501	20.728663	2.098E − 08	3.493E − 05
15	7.896	C6H10ClN5	6-chloro-n-(1-methylethyl)-1,3,5-triazine-2,4-diamine	1.8510126	0.3676839	5.818E − 05	1.27E − 05
16	4.97	C12H7NO8	6-hydroxy-5-methoxyindole glucuronide	0.0286254	62.126321	0.0003199	0.0001008
17	0.734	C20H28O2	9-cis-retinoic acid	1.6116245	0.4233558	0.0019205	0.0005299
18	8.002	C7H6O	Benzaldehyde	2.5762984	0.3179199	1.163E − 07	1.252E − 07
19	3.456	C4H5N3O	Cytosine	0.5529155	0.8961198	0.1506915	0.7413868
20	1.644	C9H13NO3	Epinephrine	1.5367492	0.6398639	1.695E − 07	0.0007399
21	7.896	C8H7N	Indole	1.3203628	0.5628054	0.00099	0.0002216
22	7.896	C9H7N	Isoquinoline	1.2759086	0.5900985	0.0042557	0.0011268
23	8.792	C23H45NO4	L-palmitoylcarnitine	1.4179083	0.5049624	0.0329971	0.0029532
24	7.885	C11H12N2O2	L-tryptophan	1.8452391	0.3639046	0.0001183	2.284E − 05
25	11.922	C26H54NO7P	Lysopc (18:0)	2.0487088	0.3510377	2.022E − 05	9.288E − 06
26	10.433	C30H52NO7P	Lysopc (22:5 (7z,10z,13z,16z,19z))	0.5879232	1.5815098	4.966E − 05	2.871E − 08
27	1.57	C9H17NO5	Pantothenic acid	1.892487	0.3008211	0.0035404	2.502E − 07
28	8.578	C42H80NO8P	Pc (14:0/20:2(11z,14z))	0.8523078	1.1325779	0.028192	5.716E − 06
29	8.583	C42H78NO8P	Pc(14:0/20:3(8z,11z,14z))	0.7721801	1.346384	0.0023297	4.262E − 08
30	8.606	C41H80NO8P	Pc(15:0/18:1(11z))	0.6693928	1.8392962	0.0037784	3.122E − 05
31	8.713	C40H80NO8P	Pc(16:0/16:0)	1.3414214	0.4943378	0.0106971	0.0049318
32	8.5	C44H84NO8P	Pc(18:1(9z)/18:1(9z))	0.8360294	1.076322	0.00924	0.0004752
33	8.616	C41H78NO8P	Pe(14:0/22:2(13z,16z))	0.6923289	1.1487602	0.0008253	0.0007498
34	8.54	C43H82NO8P	Pe(16:1(9z)/22:1(13z))	0.6367583	1.1973036	0.0005998	0.0006618
35	8.547	C43H80NO8P	Pe(22:2(13z,16z)/16:1(9z))	0.4371836	1.9951094	8.633E − 07	7.816E − 07
36	8.333	C47H86NO8P	Pe(22:2(13z,16z)/20:2(11z,14z))	1.2159935	0.3261839	0.1020484	3.323E − 05
37	5.649	C47H83O13P	Pi(18:1(9z)/20:3(8z,11z,14z))	1.3752143	0.5520982	0.0010777	0.0007957
38	5.672	C47H81O13P	Pi(22:5(7z,10z,13z,16z,19z)/16:0)	1.4501963	0.5528191	0.0006161	0.0022218
39	8.929	C42H80NO10P	Ps(18:0/18:1(9z))	0.5130888	3.3917303	0.0111159	4.035E − 05
40	5.737	C9H7NO2	Quinoline-4,8-diol	0.3408319	3.9021513	0.0038625	0.0017152
41	2.606	C17H20N4O6	Riboflavin	1.8788114	0.2936902	0.0006979	4.67E − 08
42	9.62	C41H83N2O6P	Sm(d18:0/18:1(11z))	2.0206224	0.3173536	0.00779	0.0029009
43	9.632	C41H81N2O6P	Sm(d18:1/18:1(9z))	1.5075415	0.4668141	0.0001188	4.025E − 05
44	7.343	C4H4N2O2	Uracil	1.117015	0.5900336	0.1148186	0.0024045