Corallodiscus flabellata B.L. Burtt Extracts Stimulate Diuretic Activity and Regulate the Renal Expression of Aquaporins
Table 1
Acute effect of oral administration of different C. flabellata extracts on urinary volume.
Group
Dose (mg/kg)
Urinary volume (mL/25 g)
1 h
3 h
5 h
7 h
9 h
11 h
Total in 11 h
Con
—
0.41 ± 0.06
0.34 ± 0.04
0.15 ± 0.05
0.12 ± 0.04
0.13 ± 0.10
0.13 ± 0.08
1.27 ± 0.12
HCTZ
40
0.57 ± 0.12
0.69 ± 0.09
0.31 ± 0.02
0.22 ± 0.04
0.14 ± 0.02
0.12 ± 0.04
2.06 ± 0.16
CF-L
77.5
0.35 ± 0.06
0.35 ± 0.06
0.20 ± 0.09
0.18 ± 0.11
0.22 ± 0.04
0.17 ± 0.08
1.46 ± 0.11
CF-M
155
0.37 ± 0.08
0.35 ± 0.05
0.28 ± 0.05
0.25 ± 0.04
0.25 ± 0.05
0.18 ± 0.05
1.67 ± 0.10
CF-H
310
0.44 ± 0.09
0.44 ± 0.04
0.30 ± 0.05
0.28 ± 0.10
0.27 ± 0.08
0.23 ± 0.11
1.96 ± 0.09
Values are expressed as mean ± SD of eight mice in each group. and compared to controls using Dunnett’s t-test. Daily oral administration of CF, CF-WE, CF-20, CF-30, and CF-40 occurred on five consecutive days.
