Corallodiscus flabellata B.L. Burtt Extracts Stimulate Diuretic Activity and Regulate the Renal Expression of Aquaporins
Table 2
Effects of different treatments on urine volume in mice 7 h after administration.
Group
Dose (mg/kg)
Urinary volume (mL/25 g)
First day
Second day
Third day
Fourth day
Fifth day
Con
—
1.09 ± 0.07
0.96 ± 0.18
1.04 ± 0.13
1.03 ± 0.11
1.02 ± 0.07
HCTZ
40
1.50 ± 0.21
1.56 ± 0.26
1.25 ± 0.12
1.27 ± 0.14
1.27 ± 0.19
CF
310
1.41 ± 0.09
1.32 ± 0.19
0.88 ± 0.18
1.08 ± 0.06
0.98 ± 0.23
CF-WE
82
1.42 ± 0.34
0.85 ± 0.27
0.96 ± 0.11
1.09 ± 0.15
0.98 ± 0.08
CF-20
20
1.45 ± 0.29
1.51 ± 0.20
0.96 ± 0.10
1.04 ± 0.09
0.97 ± 0.23
CF-30
20
1.54 ± 0.23
1.24 ± 0.16
0.89 ± 0.15
1.06 ± 0.09
0.89 ± 0.14
CF-40
36
1.56 ± 0.19
1.28 ± 0.18
1.22 ± 0.15
1.29 ± 0.11
1.27 ± 0.11
Values are expressed as mean ± SD of eight mice in each group. and compared to controls using Dunnett’s t-test. Daily oral administration of CF, CF-WE, CF-20, CF-30, and CF-40 occurred on five consecutive days.
