Corallodiscus flabellata B.L. Burtt Extracts Stimulate Diuretic Activity and Regulate the Renal Expression of Aquaporins

Table 3

Effects of C. flabellata extracts and hydrochlorothiazide on osmolality of urine and serum.

Group	Dose (mg/kg)	Urine osmotic (moms)	Plasma osmotic (moms)
Con	—	1025 ± 174.1	329.0 ± 23.6
HCTZ	40	1314.8 ± 180.1	328.7 ± 16.9
CF	310	1156.6 ± 156.1	331.6 ± 11.2
CF-WE	82	1212.0 ± 406.3	332.5 ± 12.7
CF-20	20	1233.8 ± 185.7	328.3 ± 7.0
CF-30	20	1209.0 ± 198.5	334.7 ± 12.1
CF-40	36	1275.6 ± 180.1	340.1 ± 8.9

Values are expressed as mean ± SD of eight mice in each group. and compared to controls using Dunnett’s t-test. Daily oral administration of CF, CF-WE, CF-20, CF-30, and CF-40 occurred on five consecutive days.