Corallodiscus flabellata B.L. Burtt Extracts Stimulate Diuretic Activity and Regulate the Renal Expression of Aquaporins

Table 4

Effects of C. flabellata extracts and hydrochlorothiazide on the urine electrolyte concentration.

Group	Dose (mg/kg)	Urinary electrolyte concentration
		Na^+ (mmol/L)	K^+ (mmol/L)	Cl^− (mmol/L)
Con	—	69.0 ± 6.5	76.4 ± 12.2	71.1 ± 4.6
HCTZ	40	86.6 ± 6.0	72.5 ± 15.0	84.5 ± 4.5
CF	310	66.9 ± 8.8	86.6 ± 1.8	73.3 ± 3.1
CF-WE	82	77.7 ± 6.9	77.9 ± 11.4	73.4 ± 4.4
CF-20	20	82.5 ± 11.9	65.4 ± 18.7	72.5 ± 7.2
CF-30	20	82.8 ± 5.6	81.3 ± 4.1	74.0 ± 3.3
CF-40	36	87.6 ± 9.7	76.5 ± 4.9	77.3 ± 4.3

Values are expressed as mean ± SD of eight mice in each group. and compared to controls using Dunnett’s t-test. Daily oral administration of CF, CF-WE, CF-20, CF-30, and CF-40 occurred on five consecutive days.