Corallodiscus flabellata B.L. Burtt Extracts Stimulate Diuretic Activity and Regulate the Renal Expression of Aquaporins

Table 5

Effect of C. flabellata extracts and hydrochlorothiazide on the serum electrolyte concentration.

Group	Dose (mg/kg)	Serum electrolyte concentrations
		Na^+ (mmol/L)	K^+ (mmol/L)	Cl^− (mmol/L)
Con	—	156.4 ± 8.1	8.7 ± 0.1	68.9 ± 1.1
HCTZ	40	143.4 ± 10.3	8.6 ± 0.1	68.0 ± 0.4
CF	310	157.5 ± 8.7	8.6 ± 0.3	68.4 ± 1.2
CF-WE	82	157.9 ± 5.9	8.5 ± 0.5	68.9 ± 0.5
CF-20	20	156.3 ± 9.0	8.0 ± 0.8	68.7 ± 0.5
CF-30	20	145.6 ± 10.2	8.2 ± 0.3	69.8 ± 0.7
CF-40	36	144.3 ± 18.4	8.4 ± 0.3	68.8 ± 0.6

Values are expressed as mean ± SD of eight mice in each group. and compared to controls using Dunnett’s t-test. Daily oral administration of CF, CF-WE, CF-20, CF-30, and CF-40 occurred on five consecutive days.