Berberine Suppressed Tumor Growth through Regulating Fatty Acid Metabolism and Triggering Cell Apoptosis via Targeting FABPs

Figure 4

The FABP inhibitor, BMS309403, could partially recapitulate the effects of berberine on MGC803 cells. (a) BMS309403 suppressed the proliferation of MGC803 cells. (b) BMS309403 induced the apoptosis of MGC803 cells, and they were statistically analyzed in (c). (d) BMS309403 treatment downregulated the protein expression of antiapoptosis protein Bcl-2 and promoted the protein expression of proapoptosis protein Bax and activated the expression of caspase3 protein, and these apoptosis-related proteins were quantified in (e). (f) BMS309403 inhibited the protein expression of key lipid metabolic enzymes FABP5 and PPARα. (g) The quantification of the protein expression of key lipid metabolic enzymes FABP5 and PPARα in MGC803 cells after BMS309403 treatment. (h) BMS309403 elevated the cellular contents and supernatant contents of the triglyceride of MGC803 cells. , , , and ns means no statistical significance.

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