Berberine Suppressed Tumor Growth through Regulating Fatty Acid Metabolism and Triggering Cell Apoptosis via Targeting FABPs

Figure 7

Berberine altered the lipid contents and key lipid metabolic enzymes in the MGC803 xenograft models. (a) Berberine treatment increased the level of TG of MGC803 xenograft tumors. Berberine had no effects on the level of T-CHO of MGC803 xenograft tumors. (b) Berberine treatment elevated the level of TG in the serum of MGC803 xenografts. Berberine had no effects on the level of T-CHO in the serum of MGC803 xenografts. (c) Berberine suppressed the protein expression of key lipid metabolic enzymes FABP4, FABP5, and PPARα of MGC803 xenograft tumors. (d) The quantification of key lipid metabolic enzymes FABP4, FABP5, and PPARα of tumor tissues from MGC803 xenografts. , , and ns means no statistical significance.

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