Evidence-Based Complementary and Alternative Medicine

Research Article

Systematic Elucidation of the Potential Mechanism of Erzhi Pill against Drug-Induced Liver Injury via Network Pharmacology Approach

Table 2

Functions of potential target genes based on KEGG pathway analysis.
TermNumber of pathway gene value
Pathways in cancerIGF1, FLT3, FGFR1, MET, PIK3CG, MMP9, NOS2, CDK2, HSP90AA1, PIK3R1, MDM2, RAC2, GSTP1, MMP2, MAPK1, FGFR2, CASP3, PPARG, EGFR, BMP2, AKT1, BRAF, MAPK81.05E – 10
Proteoglycans in cancerIGF1, SRC, FGFR1, MET, PIK3CG, MMP9, ESR1, PIK3R1, KDR, PDPK1, MDM2, MMP2, PTPN11, MAPK1, CASP3, PLAU, MAPK14, EGFR, AKT1, BRAF2.44E – 13
PI3K-Akt signaling pathwayIGF1, FGFR1, MET, PIK3CG, CDK2, IL2, HSP90AA1, PIK3R1, KDR, PDPK1, MDM2, NOS3, FGFR2, MAPK1, INSR, EGFR, AKT17.80E – 07
Rap1 signaling pathwayIGF1, SRC, FGFR1, MET, PIK3CG, PIK3R1, KDR, RAC2, FGFR2, MAPK1, INSR, MAPK14, EGFR, AKT1, BRAF,5.12E – 08
FoxO signaling pathwayIGF1, PIK3CG, CDK2, PIK3R1, PDPK1, MDM2, SOD2, MAPK1, INSR, MAPK14, EGFR, AKT1, MAPK8, BRAF1.74E – 09
Focal adhesionIGF1, SRC, MET, PIK3CG, PIK3R1, KDR, MYLK, PDPK1, RAC2, MAPK1, EGFR, AKT1, MAPK8, BRAF3.09E – 07
Ras signaling pathwayIGF1, PIK3R1, KDR, RAC2, FGFR1, PTPN11, MET, MAPK1, FGFR2, PIK3CG, INSR, EGFR, AKT1, MAPK88.97E – 07
Prostate cancerIGF1, FGFR1, PIK3CG, CDK2, PIK3R1, HSP90AA1, PDPK1, MDM2, FGFR2, MAPK1, EGFR, AKT1, BRAF1.42E – 10
Insulin resistanceNR1H3, PIK3CG, PYGL, PTPN1, PIK3R1, PDPK1, NOS3, PTPN11, INSR, PPARA, AKT1, NR1H2, MAPK81.62E – 09
Estrogen signaling pathwayHSP90AA1, PIK3R1, HSPA8, ESR1, SRC, NOS3, MMP2, MAPK1, PIK3CG, MMP9, EGFR, AKT18.25E – 09
MAPK signaling pathwayMAPT, HSPA8, RAC2, FGFR1, MAPK1, FGFR2, CASP3, MAPK14, EGFR, AKT1, BRAF, MAPK89.21E – 05
Hepatitis CPIK3R1, NR1H3, PDPK1, MAPK1, PIK3CG, MAPK14, PPARA, EGFR, AKT1, BRAF, MAPK81.68E – 06
Regulation of actin cytoskeletonPIK3R1, MYLK, SRC, RAC2, FGFR1, MAPK1, FGFR2, PIK3CG, EGFR, F2, BRAF9.31E – 05
MelanomaPIK3R1, IGF1, MDM2, FGFR1, MET, MAPK1, PIK3CG, EGFR, AKT1, BRAF6.49E – 08
Progesterone-mediated oocyte maturationHSP90AA1, PIK3R1, IGF1, MAPK1, PIK3CG, MAPK14, CDK2, AKT1, BRAF, MAPK83.88E – 07
Sphingolipid signaling pathwayPIK3R1, PDPK1, RAC2, ABCC1, NOS3, MAPK1, PIK3CG, MAPK14, AKT1, MAPK85.91E – 06
Insulin signaling pathwayPIK3R1, PDPK1, MAPK1, PIK3CG, INSR, PYGL, PTPN1, AKT1, BRAF, MAPK81.85E – 05
VEGF signaling pathwayPIK3R1, KDR, SRC, RAC2, NOS3, MAPK1, PIK3CG, MAPK14, AKT12.81E – 07
Central carbon metabolism in cancerPIK3R1, FLT3, FGFR1, MET, MAPK1, FGFR2, PIK3CG, EGFR, AKT14.11E – 07
HIF-1 signaling pathwayPIK3R1, IGF1, NOS3, MAPK1, PIK3CG, INSR, NOS2, EGFR, AKT19.27E – 06