Enhancing and Complementary Mechanisms of Synergistic Action of Acori Tatarinowii Rhizoma and Codonopsis Radix for Alzheimer’s Disease Based on Systems Pharmacology

Table 1

Information on the active ingredients in ATR and CR.

ID	Molecule name	Structure	OB (%)	DL
CR1	Poriferasta-7,22E-dien-3beta-ol		42.98	0.76
CR2	2-methoxyfuranodiene		53.58	0.13
CR5	EIC		41.9	0.14
CR14	Methyl linoleate		41.93	0.17
CR16	(+/−)-Isoborneol		86.98	0.05
CR21	Perlolyrine		65.95	0.27
CR28	DIOP		43.59	0.39
CR32	ZINC03978781		43.83	0.76
CR37	Stigmasterol		43.83	0.76
CR38	Syringin		14.64	0.32
CR43	Tectorigenin		28.41	0.27
CR45	7-Methoxy-2-methyl isoflavone		42.56	0.2
CR48	Spinasterol		42.98	0.76
CR49	Atractylenolide II		47.5	0.15
CR52	Atractylenolide III		68.11	0.17
CR61	Frutinone A		65.9	0.34
CR63	Luteolin		36.16	0.25
CR67	Taraxerol		38.4	0.77
CR69	Stigmast-7-enol		37.42	0.75
CR70	Norharman		18.88	0.08
CR73	3-Beta-hydroxymethyllenetanshiquinone		32.16	0.41
CR75	HMF		45.07	0.02
CR76	Methyl icosa-11,14-dienoate		39.67	0.23
CR77	Apigenin		23.06	0.21
CR81	(1R)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indol-2-ium-1-carboxylate		52.9	0.13
CR97	5-Alpha-stigmastan-3,6-dione		33.12	0.79
CR99	7-(Beta-xylosyl)cephalomannine_qt		38.33	0.29
CR101	Codonopsine		45.83	0.13
CR103	Daturilin		50.37	0.77
CR106	Glycitein		50.48	0.24
CR112	Spinoside A		39.97	0.4
CR113	(8S,9S,10R,13R,14S,17R)-17-[(E,2R,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-1,2,4,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one		45.4	0.76
CR117	11-Hydroxyrankinidine		40	0.66
CR123	Ethyl-β-D-fructofuranoside		33.84	0.15
CR130	Furanodiene		45.11	0.1
CR132	(+)-Beta-pinene		44.77	0.05
ATR3	Vanillic acid		35.47	0.04
ATR6	(−)-Alloaromadendrene		54.04	0.1
ATR12	Calarene		52.16	0.11
ATR15	p-MCA		31	0.05
ATR19	Marmesin		50.28	0.18
ATR20	Majudin		42.21	0.13
ATR23	(−)-Caryophyllene oxide		32.67	0.13
ATR28	beta-Asarone		35.61	0.06
ATR30	beta-Gurjunene		51.36	0.1
ATR35	beta-Cubebene		32.81	0.11
ATR40	2′-0.1Methylisoliquiritigenin		75.86	0.17
ATR50	(+)-Ledene		51.84	0.1
ATR53	(+)-alpha-Longipinene		57.47	0.12
ATR54	8-Isopentenyl-kaempferol		38.04	0.39
ATR55	Aminacrine		35	0.12
ATR57	Aristolene		52.2	0.11
ATR58	Aristolone		45.31	0.13
ATR59	Azaron		38.39	0.06
ATR63	Bisasarcin		18.55	0.5
ATR65	Calamendiol		61.13	0.11
ATR73	Isocalamendiol		57.63	0.11
ATR78	Longicyclene		46.07	0.15
ATR79	Murolan-3,9(11)-diene-10-peroxy		36.72	0.11
ATR81	Patchoulene		49.06	0.11
ATR84	Spathulenol		81.61	0.12
ATR87	α-Gurjunene		52.57	0.1
ATR88	α-Panasinsene		56.77	0.12
ATR89	(1R,3aS,4R,6aS)-1,4-bis(3,4-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[4,3-c]furan		52.35	0.62
ATR91	Cycloartenol		38.69	0.78
ATR93	Kaempferol		41.88	0.24
ATR98	(−)-alpha-Cedrene		55.56	0.1
ATR102	p-Coumaric acid		43.29	0.04