Research Article

Enhancing and Complementary Mechanisms of Synergistic Action of Acori Tatarinowii Rhizoma and Codonopsis Radix for Alzheimer’s Disease Based on Systems Pharmacology

Table 2

Information on AD-related targets.

GeneTarget nameUniProt ID

ABCA1ATP-binding cassette subfamily A member 1O95477
ABCB1Multidrug resistance protein 1P08183
ACHEAcetylcholinesteraseP22303
ADH1CAlcohol dehydrogenase 1CP00326
ADRA2CAlpha-2C adrenergic receptorP18825
ADRB2Beta-2 adrenergic receptorP07550
AHRAryl hydrocarbon receptorP35869
ALOX5Arachidonate 5-lipoxygenaseP09917
APPAmyloid beta A4 proteinP05067
BACE1Beta-secretase 1P56817
BAXApoptosis regulator BAXQ07812
BCHECholinesteraseP06276
BCL2Apoptosis regulator Bcl-2P10415
CALM1CalmodulinP0DP23
CASP3Caspase-3P42574
CASP7Caspase-7P55210
CDK5Cyclin-dependent kinase 5 (CDK5)Q00535
CHRM1Muscarinic acetylcholine receptor M1P11229
CHRM2Muscarinic acetylcholine receptor M2P08172
CHRM3Muscarinic acetylcholine receptor M3P20309
CHRNA2Neuronal acetylcholine receptor subunit alpha-2Q15822
CHRNA7Neuronal acetylcholine receptor protein, alpha-7 chainP36544
CHUKInhibitor of NF-kappa-B kinase (IKK)O15111
CYP1A2Cytochrome P450 1A2P05177
CYP2A6Cytochrome P450 2A6P11509
CYP2D6Cytochrome P450 2D6 (2D6)P10635
CYP3A4Cytochrome P450 3A4P08684
DIO1Type I iodothyronine deiodinaseP49895
ESR1Estrogen receptorP03372
F2ThrombinP00734
F7Coagulation factor VIIP08709
FLT3Tyrosine-protein kinase receptor FLT3P36888
GABRA1Gamma-aminobutyric acid receptor subunit alpha-1P14867
GABRA2Gamma-aminobutyric-acid receptor alpha-2 subunitP47869
GABRA5Gamma-aminobutyric-acid receptor alpha-5 subunitP31644
GSK3BGlycogen synthase kinase-3 betaP49841
HMOX1Heme oxygenase 1P09601
HTR2A5-Hydroxytryptamine 2A receptorP28223
IGF1RInsulin-like growth factor 1 receptorP08069
IKBKBInhibitor of nuclear factor kappa-B kinase subunit betaO14920
IL10Interleukin-10P22301
IL1BInterleukin-1 betaP01584
INSInsulinP01308
INSRInsulin receptorP06213
KDRVascular endothelial growth factor receptor 2P35968
MAOAAmine oxidase [flavin-containing] AP21397
MAOBAmine oxidase [flavin-containing] BP27338
MAPK10Mitogen-activated protein kinase 10P53779
METHepatocyte growth factor receptorP08581
NOS3Nitric-oxide synthase, endothelialP29474
NR1I2Nuclear receptor subfamily 1 group I member 2O75469
PLAUUrokinase-type plasminogen activatorP00749
PPARGPeroxisome proliferator activated receptor gammaP37231
PTGESProstaglandin E synthaseO14684
PTGS1Prostaglandin G/H synthase 1P23219
PTGS2Prostaglandin G/H synthase 2P35354
RXRARetinoic acid receptor RXR-alphaP19793
RXRGRetinoic acid receptor RXR-gammaP48443
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4P14672
SOAT1Acyl-cholesterol acyltransferase 1P35610
TNFTumor necrosis factorP01375
VEGFAVascular endothelial growth factor AP15692