Research Article
Effect of Different-Volume Fluid Resuscitation on Organ Functions in Severe Acute Pancreatitis and Therapeutic Effect of Poria cocos
Table 1
Comparison of organ injury indexes between groups.
| | | SHAM (n = 6) | NFR (n = 6) | LFR (n = 6) | HFR (n = 6) | FL + HFR (n = 6) |
| | Hematologic analysis | | AMY (U/L) | 992.2 ± 152.4 | 4618.7 ± 1239 | 3233.8 ± 1064.6 | 3292.3 ± 541.6# | 3437.2 ± 980.8 | | WBC (109/L) | 9.6 ± 1.3 | 12.2 ± 1.8 | 9.3 ± 2.8 | 8.1 ± 0.9# | 10.6 ± 2.5 | | HCT (%) | 45.3 ± 3.6 | 51.0 ± 5.1 | 50.5 ± 2.8 | 52.0 ± 0.9 | 47.9 ± 2.5 | | BUN (mmol/L) | 3.0 ± 0.6 | 12.9 ± 4.6 | 4.3 ± 0.4# | 6.4 ± 1.1#▼ | 3.3 ± 0.4#▼▲ | | Cr (μmol/L) | 28.7 ± 2.9 | 44.8 ± 15.4 | 30.7 ± 2.7# | 41.5 ± 7.2▼ | 27.0 ± 1.1#▲ | | LAC (mmol/L) | 4.1 ± 0.9 | 5.6 ± 1.2 | 5.8 ± 1.0 | 4.0 ± 0.4#▼ | 5.2 ± 0.5▲ | | Ph | 7.37 ± 0.1 | 7.22 ± 0.1 | 7.27 ± 0.04 | 7.30 ± 0.1# | 7.16 ± 0.02▼▲ | | PaO2 (mmHg) | 92.6 ± 6.9 | 75.3 ± 2.6 | 75.9 ± 7.6 | 122.0 ± 0.7# | 100.2 ± 3.5#▲ | | SaO2 (%) | 90.2 ± 3.2 | 86.3 ± 1.6 | 86.5 ± 7.0 | 85.9 ± 1.9 | 93.6 ± 1.0#▼▲ | | Biological records | | IAC (cm) | 16.2 ± 0.8 | 16.6 ± 0.4 | 16.7 ± 0.4 | 16.6 ± 0.5 | 16.8 ± 0.3 | | ACI (cm) | 0.5 ± 0.3 | 1.2 ± 0.2 | 1.3 ± 0.4 | 1.7 ± 0.4# | 2.1 ± 0.8# | | Ascites (mL) | 0.6 ± 0.2 | 5.2 ± 0.3 | 4.9 ± 2.0 | 12.8 ± 1.8#▼ | 9.9 ± 2.1#▼ | | Urine output (mL) | 2.2 ± 0.7 | 0.9 ± 0.5 | 2.2 ± 0.4# | 3.5 ± 1.7# | 2.4 ± 1.4# | | Glycocalyx compositions | | MMPs (U/mL) | 231.6 ± 4.7 | 297.1 ± 21.1 | 273.8 ± 20.4 | 337.4 ± 17.3# | 274.9 ± 22.2▲ | | SCD-1 (ng/mL) | 1.5 ± 0.2 | 1.3 ± 0.1 | 1.7 ± 0.4 | 1.4 ± 0.2 | 1.2 ± 0.1▼ | | sCD44 (ng/mL) | 8.0 ± 0.9 | 8.9 ± 0.9 | 8.9 ± 0.4 | 8.7 ± 0.6 | 9.6 ± 0.4▲ | | HA (ng/mL) | 105.9 ± 43 | 251.2 ± 107.7 | 143.4 ± 17.2 | 143.2 ± 38.2 | 252.6 ± 55.3▼▲ | | Pathological scores | | Pancreas | 0.7 ± 0.5 | 8.3 ± 0.5 | 6.8 ± 0.6# | 6.2 ± 0.5# | 6.0 ± 0.4# | | Kidney | 0.7 ± 0.5 | 7.3 ± 0.8 | 6.0 ± 0.6# | 7.3 ± 0.8 | 3.5 ± 0.5#▲ |
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SHAM: sham; NFR: nonfluid resuscitation; LFR: low-volume fluid resuscitation; HFR: high-volume fluid resuscitation; FL + HFR: Poria cocos combined with high-volume fluid resuscitation. AMY: amylase; WBC: white blood cells; HCT: hematocrit; BUN: blood urea nitrogen; Cr: creatinine; LAC: lactate; PaO 2: partial pressure of oxygen; SaO 2: arterial oxygen saturation; IAC: initial abdominal circumference; ACI: abdominal circumference increment; MMPs: matrix metalloproteinases; SCD-1: syndecan-1; sCD44: soluble CD44; HA: plasma: hyaluronic acid; ∗, #, ▼, ▲Compared with the SHAM, NFR, LFR, and HFR groups, respectively, . |
