Abyssinone V-4′ Methyl Ether, a Flavanone Isolated from Erythrina droogmansiana, Exhibits Cytotoxic Effects on Human Breast Cancer Cells by Induction of Apoptosis and Suppression of Invasion

Table 2

Comparative CC₅₀ and selective cytotoxicity index (SCI) values of AVME in tumoral and non‐tumoral cell lines.

CC50 (µM) [mean ± SD]				SCI
Tumoral cell lines		Non‐tumoral cell lines		CC50 HUVEC cells/CC50 tumoral cells
MCF-7	21 ± 3.51	HUVEC	27 ± 2.51	1.3
MDA-MB-231	20 ± 2.18	MRC-5	30 ± 0.78	1.4
4T1	18 ± 1.11	NIH-3T3	21 ± 0.89	1.5
SK-MEL-28	18 ± 3.1			1.5
SF-295	21 ± 2.03			1.3

CC₅₀: concentration of AVME which results in 50% of cell viability. SCI: selective cytotoxicity index. The results are expressed as mean ± SD of at least 3 independent experiments. The results are expressed as mean ± SD of at least 3 independent experiments. Selectivity index: ∼1.3 (CC₅₀ nontumoral cells/CC₅₀ tumoral cells).