Advances in the Study of the Potential Hepatotoxic Components and Mechanism of Polygonum multiflorum

Table 1

Retrospective analysis on cases of liver injury of Polygonum multiflorum.

Case	Age	Duration of intake, day	Preparations	Presenting PM	Extrahepatic manifestation	Type of liver injury	Reference
264	5～63	7～365	Shou Wu tablet, Yangxue Shengfa capsule, Yanshou tablet, Jingwu capsule, Yishen Wufa oral liquid, Qibao Meiran pill, Tianma Shouwu tablet, Huo Li Su oral liquid, Geng Nian An tablet, Kunbao pill, Xinyuan capsule, Zhi Shou Wu granule, Renshen Shouwu capsule, Fu Fang Shou Wu oral liquid, Shou Wu pill, Anshen Bunao liquid, Jiang Zhi Ling tablet, Bantu pill, Bushen Yishou capsule, Huichun Ruyi capsule, Shenbao tablet, Jiangzhi Huazhuo capsule, Heishou Shengfa granule, Baishi pill, Shou Wu tea, etc.	PPM	Fever, fatigue, loss of appetite, jaundice, erythra, myalgia, nausea and vomiting, etc.	Mixed, hepatocellular, cholestasis	[10, 11]
214	19～78	3～120	He Shou Wu powder, He Shou Wu tea, He Shou Wu wine, etc.	Raw PM	Fever, fatigue, loss of appetite, jaundice, erythra, myalgia, nausea and vomiting, ascites, liver-palms, gray stool, etc.	Mixed, hepatocellular, cholestasis	[9, 12]
5	36～60	30～90	Runzao Zhiyang capsule	raw PM and PPM	Fever, fatigue, loss of appetite, jaundice, erythra, myalgia, nausea and vomiting, ascites, liver-palms, gray stool, etc.	Mixed, hepatocellular, cholestasis	[10, 13]
326	19～70	5～180	Huangjing Zanyu capsule, Huichun Ruyi capsule, Shenjiao capsule, He Shou Wu powder, He Shou Wu tea, He Shou Wu wine, decoction containing PM, herbal paste, healthcare product, etc.	PM	Fever, fatigue, loss of appetite, jaundice, erythra, myalgia, nausea and vomiting, ascites, liver-palms, gray stool, abdominal distension, etc.	Mixed, hepatocellular, cholestasis	[7, 14]

Note. PM means Polygonum multiflorum; the literature does not clearly indicate whether it is raw PM or PPM.