Efficacy and Safety of Tetrahydrocurcuminoids for the Treatment of Canker Sore and Gingivitis

Table 1

Clinical signs and symptoms before and after treatment with THCs in canker sore patients.

Signs and symptoms	Baseline		Treatment with THCs				Cochran’s Q test	value
	Day 0		Day 14		Day 21
	N	N%	N	N%	N	N%
Bleeding	2	6.5	0	0.0	0	0.0	4	0.135^a
Pain at the site	23	74.2	13	41.9	2	6.7	30.1	<0.001^b
Burning at the site	16	51.6	2	6.5	1	3.3	28.1	<0.001^b
Reddening at the site	21	67.7	8	25.8	0	0.0	27.64	<0.001^b
Inflammation at the site	0	0.0	0	0.0	0	0.0	—	—^c
Swelling and pain at lymph node	0	0.0	0	0.0	0	0.0	—	—^c
Difficulty in chewing	12	38.7	5	16.1	0	0.0	16.77	<0.001^b
Difficulty in swallowing	18	58.1	6	19.4	1	3.3	22.9	<0.001^b
Injury to mouth	1	3.2	—	—	—	—	—	—

N = patient count; N% = percentage of patient count. Cochran’s Q test was performed for the comparison of signs and symptoms before and after treatment. ^aTHCs treatment prevented further deterioration of the gums, . ^bSignificant reduction after THCs treatment, . ^cNo statistical test was performed since no change was observed between baseline and treatment.