Efficacy and Safety of Tetrahydrocurcuminoids for the Treatment of Canker Sore and Gingivitis

Table 2

Clinical signs and symptoms before and after treatment with THCs in gingivitis.

Signs and symptoms		Baseline		Treatment with THCs
		Day 0		Day 14		Day 21
		N	N%	N	N%	N	N%
Taste acceptability^a	Acceptable	29	100.0	29	100.0	29	100.0
	Unacceptable	0	0.0	0	0.0	0	0.0
Burning sensation^b	Absent	16	55.2	27	93.1	29	100.0
	Present	13	44.8	2	6.9	0	0.0
Dryness/soreness^c	Absent	28	96.6	29	100.0	29	100.0
	Present	1	3.4	0	0.0	0	0.0
Ulcer formation^c	Absent	27	93.1	29	100.0	29	100.0
	Present	2	6.9	0	0.0	0	0.0
Staining of teeth^c	Absent	15	51.7	13	44.8	18	62.1
	Present	14	48.3	16	55.2	11	37.9
Staining of tongue^a	Absent	28	96.6	29	100.0	28	96.5
	Present	1	3.4	0	0.0	1	3.5
Allergy^a	Absent	29	100.0	29	100.0	29	100.0
	Present	0	0.0	0	0.0	0	0.0

N = patient count; N% = percentage of patient count. McNemar’s statistical test was used for the comparison of various gingivitis criteria (signs and symptoms) before and after treatment. ^aNo statistical test was performed since the patient’s response was constant between baseline and treatment. ^bBurning sensation was significantly reduced in patients after treatment (days 14 and 21) compared to baseline, . ^cNo significant difference was observed between the baseline and THCs treatment, .