Therapeutic and Preventive Effects of Olea europaea Extract on Indomethacin-Induced Small Intestinal Injury Model in Rats

Figure 4

Histological changes in the small intestine. (a) Crypt hyperplasia score was decreased in all doses of O. europaea compared to the control group in the therapeutic experiment. However, only O. europaea at a dosage of 200 mg/kg was effective in the preventive experiment. (b) Plasma cell infiltration scores were lower in the dosage of 200 and 400 mg/kg of O. europaea in the therapeutic experiment. Although, no significant difference in groups of preventive experiment was seen. (c) Edema score was decreased in the dosage of 100 mg/kg of O. europaea in the therapeutic experiment and all doses in the preventive experiment. (d) Congestion scores were lower in a dosage of 200 mg/kg of O. europaea in both experiments. (e) All groups treated with O. europaea in therapeutic and preventive experiments showed a significant reduction in eosinophil scores. (f) Villus length-to-crypt depth ratio was not changed between groups of both experiments. Data in sections A to F are expressed as mean ± standard deviation. (g) Presence of neutrophils is expressed as percent indicating the percentage of the study population that was found to show at least one neutrophil during our investigations. We did not find any statistically significant difference anywhere in our experiments. (h) Percentage of destructed villus architecture was not different between any of the study groups. value <0.05.

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