Review Article

Pharmacological Activity of Eriodictyol: The Major Natural Polyphenolic Flavanone

Figure 3

Neuroprotective effects of eriodictyol. Eriodictyol is reported to provide protection via its antioxidant nature by activation of Nrf2/HO-1 cytoprotective pathway. Moreover, Nrf2/HO-1 pathway protects H2O2-induced neurotoxicity in prostate cancer cells (PC12), and amyloid-β in neurons, while having anti-inflammatory effects involving MAPK, NF-κB pathway.