Evidence-Based Complementary and Alternative Medicine

Research Article

In Vivo Antimalarial Evaluation of Crude Extract, Solvent Fractions, and TLC-Isolated Compounds from Olea europaea Linn subsp. cuspidata (Oleaceae)

Table 4

Effect of the crude extract of O. europaea on mean survival time and body weight of P. berghei infected mice.


Treatment	Dose (mg/kg)	Body weight (g) ± SEM			MST (day) ± SEM
Treatment	Dose (mg/kg)	D₀	D₄	% change	MST (day) ± SEM

Crude extract	200	31.34 ± 1.01	29.89 ± 0.98	−4.63	7.83 ± 0.31
	400	33.35 ± 0.61	31.97 ± 0.77	−4.14^a1	9.83 ± 0.48^a2b1
	600	33.07 ± 1.24	33.08 ± 1.39	0.03^a3	10.67 ± 0.49^a3b2
Dist. water	10 ml/kg	32.97 ± 0.72	28.42 ± 0.23	−13.80	7.33 ± 0.49
Chloroquine	25	29.62 ± 1.38	31.85 ± 1.05	7.53^a3b2c2d1	ND

Values are expressed as mean ± SEM; n = 6; a = compared to negative control; b = compared to 200 mg/kg; c = to 400 mg/kg; d = compared to 600 mg/kg; ; ; . There was significant difference between day 0 and 4 within the group. D₀ = pretreatment on day zero; D₄ = posttreatment on day five; ND = no death within the 28-day follow-up.