In Vivo Antimalarial Evaluation of Crude Extract, Solvent Fractions, and TLC-Isolated Compounds from Olea europaea Linn subsp. cuspidata (Oleaceae)

Table 5

Effect of the aqueous, butanol, and chloroform fractions of O. europaea on parasitaemia of P. berghei infected mice.

Treatment	Dose (mg/kg)	Antimalarial activities
		% parasitaemia ± SEM	% suppression
Butanol fraction	100	32.86 ± 1.24	26.07^a3
	200	29.08 ± 0.53	34.58^a3
	400	24.26 ± 0.17	45.42^a3b2
Chloroform fraction	100	35.94 ± 1.83	19.15^a1
	200	34.12 ± 2.66	23.24^a2
	400	31.81 ± 0.79	28.44^a2
Aqueous fraction	100	37.50 ± 2.51	15.64
	200	35.68 ± 1.47	19.73^a1
	400	33.38 ± 1.08	24.90^a2
Dist. water	10 ml/kg	44.45 ± 2.21	0.00
Chloroquine	25	0.00	100.00^AD3

Values are expressed as mean ± SEM; n = 6; a = compared to negative control; AD = compared to all doses; b = compared to 100 mg/kg of the butanol fraction; ; ; .