In Vivo Antimalarial Evaluation of Crude Extract, Solvent Fractions, and TLC-Isolated Compounds from Olea europaea Linn subsp. cuspidata (Oleaceae)
Table 6
Effect of the aqueous, butanol, and chloroform fractions of O. europaea on mean survival time and body weight of P. berghei infected mice.
Treatment
Dose (mg/kg)
Body weight (g) ± SEM
MST (day) ± SEM
D0
D4
% change
Butanol fraction
100
31.67 ± 0.69
30.16 ± 0.68
−4.77
7.50 ± 0.22
200
31.02 ± 0.61
30.45 ± 0.95
−1.84
8.33 ± 0.49
400
29.88 ± 0.52
30.08 ± 0.76
0.67a1
10.17 ± 0.48a2b2
Chloroform fraction
100
25.27 ± 1.26
23.36 ± 1.12
−7.56
7.33 ± 0.33
200
26.73 ± 1.02
26.11 ± 0.90
−2.32
7.67 ± 0.48
400
27.83 ± 0.77
26.17 ± 0.55
−5.96
7.83 ± 0.31
Aqueous fraction
100
29.10 ± 0.45
27.93 ± 0.82
−4.02
7.17 ± 0.31
200
27.67 ± 0.11
26.71 ± 0.57
−3.47
7.67 ± 0.33
400
27.48 ± 1.13
26.64 ± 1.23
−3.06
8.17 ± 0.48
Dist. water
10 ml/kg
30.15 ± 0.68
27.71 ± 0.97
−8.09
7.17 ± 0.54
Chloroquine
25
28.02 ± 0.27
27.85 ± 0.49
−0.61a1
ND
Values are expressed as mean ± SEM; n = 6; a = compared to negative control; b = compared to 100 mg/kg of butanol fraction; ;;. There was significant difference between day 0 and 4 within the group. D0 = pretreatment on day zero; D4 = posttreatment on day five; ND = no death within 28 days.
