Evidence-Based Complementary and Alternative Medicine

Research Article

In Vivo Antimalarial Evaluation of Crude Extract, Solvent Fractions, and TLC-Isolated Compounds from Olea europaea Linn subsp. cuspidata (Oleaceae)

Table 8

Effect of compounds C and D on body weight and mean survival time of P. berghei infected mice.


Treatment	Dose (mg/kg)	Body weight (g) ± SEM			MST (day) ± SEM
Treatment	Dose (mg/kg)	D₀	D₄	% change	MST (day) ± SEM

Compound C	100	25.40 ± 0.57	23.96 ± 0.59	−5.67	7.89 ± 0.16
Compound C	200	25.03 ± 0.52	24.47 ± 0.52	−2.24	8.81 ± 0.19^a3
Compound D	100	24.47 ± 0.40	22.70 ± 0.70	−7.23	7.25 ± 0.48
Compound D	200	24.10 ± 0.66	23.40 ± 0.72	−2.90	8.52 ± 0.45^a1
Dist. water	10 ml/kg	26.13 ± 0.22	23.65 ± 0.50	−9.49	7.02 ± 0.24
Chloroquine	25	25.53 ± 0.72	26.28 ± 0.75	2.94^ab1	ND

Values are expressed as mean ± SEM; n = 6; a = compared to negative control; b = compared to 100 mg/kg (compound D). There was significant difference between day 0 and 4 within the group. ; ; D₀ = pretreatment on day zero; D₄ = post-reatment on day five; ND = no death within 28 days.