The Effects of Yuan-Zhi Decoction and Its Active Ingredients in Both In Vivo and In Vitro Models of Chronic Cerebral Hypoperfusion by Regulating the Levels of Aβ and Autophagy

<div>Experimental design of the in vivo (a) and in vitro (b) CCH models. Chemical structure of tenuigenin (c) and β-asarone (d). MWM, Morris water maze; PA, passive avoidance; SAC, sacrificed; control: control group; model: model group; sham: sham-operated group; YZDH: high-dose Yuan-Zhi decoction (20 g/(kg·d)); YZDM: medium-dose Yuan-Zhi decoction (10 g/(kg·d)); YZDL: low-dose Yuan-Zhi decoction (5 g/(kg·d)); DNZ: donepezil hydrochloride; H-H, hypoxia-hypoglycemia; TEN: tenuigenin; 3-MA: 3-methyladenine.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 1: The Effects of Yuan-Zhi Decoction and Its Active Ingredients in Both In Vivo and In Vitro Models of Chronic Cerebral Hypoperfusion by Regulating the Levels of Aβ and Autophagy

Figure 1 | The Effects of Yuan-Zhi Decoction and Its Active Ingredients in Both In Vivo and In Vitro Models of Chronic Cerebral Hypoperfusion by Regulating the Levels of Aβ and Autophagy 