The Effects of Yuan-Zhi Decoction and Its Active Ingredients in Both In Vivo and In Vitro Models of Chronic Cerebral Hypoperfusion by Regulating the Levels of Aβ and Autophagy

Figure 2

Morris water maze test evaluating spatial learning and memory ability. Escape latency (a) and search distance (b) in the hidden platform task. (c) Time spent in the target quadrant in the probe trial. (d) Representative swimming paths of spatial probe trial. 1, 2, 3, and 4 represent the 4 quadrants, respectively, the blue circle is the location of the original platform, the black square is the entry point for the rat, and the blue square is the exit point. Data are presented as mean ± SD (n = 5–6). , vs control group; , , vs model group. i/control: control group, ii/model: model group, iii/sham: sham-operated group, iv/YZDH: high-dose Yuan-Zhi decoction group (20 g/(kg·d)), v/YZDM: medium-dose Yuan-Zhi decoction group (10 g/(kg·d)), vi/YZDL: low-dose Yuan-Zhi decoction group (5 g/(kg·d)), vii/DNZ: donepezil hydrochloride group.

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